Photodynamic Therapy for Leiomyosarcoma: In vitro study

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Rajaa S. Abbas
Eman H. Y. Al-Taee
Ali S. Mahmood

Abstract

Leiomyosarcoma (smooth muscle tumor) is a rare type of a malignant neoplasm of smooth
muscle. It is a resistant cancer, generally not very responsive to chemotherapy, radiationand surgery.The
aim of this study was to evaluate photodynamic therapy (PDT) as a possible basis for treatment using
(650 nm)diode laser with methyleneblue (MB) as a photosensitizer on leiomyosarcoma (LMS)cell line
(L20B) in vitro. The cytotoxic effects of 650nm diode laser 0.052 W/cm2 (power density) at different
exposure time (10, 20, and 30 min) with methylene blue at different concentrations (0.01% ,0.1 % ,1%)
was investigated on LMS cell line (L20 B). The cytotoxic effect of laser was increased with increasing
irradiation time for a certain concentration of methylene blue. The exposure time 30 min of diode laser
with 1% (MB) has the great inhibitory rate(IR)for LMS cells growth which reaches to 80.46% and
reducing the proliferation rate (PR) which reaches to 19.54%.

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How to Cite
[1]
R. S. Abbas, E. H. Y. Al-Taee, and A. S. Mahmood, “Photodynamic Therapy for Leiomyosarcoma: In vitro study”, IJL, vol. 11, no. B, pp. 1–7, Feb. 2019, doi: 10.31900/ijl.v11iB.85.
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How to Cite

[1]
R. S. Abbas, E. H. Y. Al-Taee, and A. S. Mahmood, “Photodynamic Therapy for Leiomyosarcoma: In vitro study”, IJL, vol. 11, no. B, pp. 1–7, Feb. 2019, doi: 10.31900/ijl.v11iB.85.

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